Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration
| dc.contributor.author | Balbach, Melanie | |
| dc.contributor.author | Fushimi, Makoto | |
| dc.contributor.author | Huggins, David | |
| dc.contributor.author | Steegborn, Clemens | |
| dc.contributor.author | Meinke, Peter | |
| dc.contributor.author | Levin, Lonny | |
| dc.contributor.author | Buck, Jochen | |
| dc.date.accessioned | 2020-05-14T14:13:04Z | |
| dc.date.available | 2020-05-14T14:13:04Z | |
| dc.date.issued | 2020-04 | |
| dc.description.abstract | Efforts to develop new male or female non-hormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third assumption and propose that despite its wide expression, soluble adenylyl cyclase (sAC: ADCY10), which is essential for male fertility, is a valid target. We hypothesize that an acute-acting sAC inhibitor may provide orally available, on-demand, non-hormonal contraception for men without adverse, mechanism-based effects. To test this concept, we describe a collaboration between academia and the unique capabilities of a public-private drug discovery institute | en_US |
| dc.identifier.pmid | 32307523 | |
| dc.identifier.uri | https://hdl.handle.net/1813/69929 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Oxford Academic | en_US |
| dc.relation.doi | https://doi.org/10.1093/biolre/ioaa052 | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | contraceptives | en_US |
| dc.subject | drug discovery | en_US |
| dc.title | Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration | en_US |
| dc.type | article | en_US |
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