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Data from: Evolutionary genomic analyses of canine E. coli infections identifies a relic capsular locus associated with resistance to multiple classes of antimicrobial drugs

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dc.contributor.authorCeres, Kristina
dc.contributor.authorZehr, Jordan D.
dc.contributor.authorMurrell, Chloe
dc.contributor.authorMillet, Jean K.
dc.contributor.authorSun, Qi
dc.contributor.authorMcQueary, Holly C.
dc.contributor.authorHorton, Alanna
dc.contributor.authorCazer, Casey
dc.contributor.authorSams, Kelly
dc.contributor.authorReboul, Guillaume
dc.contributor.authorAndreopoulos, William B.
dc.contributor.authorMitchell, Patrick K.
dc.contributor.authorAnderson Renee
dc.contributor.authorFranklin-Guild, Rebecca
dc.contributor.authorCronk, Brittany D.
dc.contributor.authorStanhope, Bryce J.
dc.contributor.authorBurbick, Claire R.
dc.contributor.authorWolking, Rebecca
dc.contributor.authorPeak, Laura
dc.contributor.authorZhang, Yan
dc.contributor.authorMcDowall, Rebeccah
dc.contributor.authorKrishnamurthy, Aparna
dc.contributor.authorSlavic, Durda
dc.contributor.authorSekhon, Prabhjot Kaur
dc.contributor.authorTyson, Gregory H.
dc.contributor.authorCeric, Olgica
dc.contributor.authorStanhope, Michael J.
dc.contributor.authorGoodman, Laura B.
dc.date.accessioned2024-02-28T20:52:29Z
dc.date.available2024-02-28T20:52:29Z
dc.date.issued2024
dc.descriptionPlease cite as: Kristina Ceres, Jordan D. Zehr, Chloe Murrell, Jean K. Millet, Qi Sun, Holly C. McQueary, Alanna Horton, Casey Cazer, Kelly Sams, Guillaume Reboul, William B. Andreopoulos, Patrick K. Mitchell, Renee Anderson, Rebecca Franklin-Guild, Brittany D. Cronk, Bryce J. Stanhope, Claire R. Burbick, Rebecca Wolking, Laura Peak, Yan Zhang, Rebeccah McDowall, Aparna Krishnamurthy, Durda Slavic, Prabhjot Kaur Sekhon, Gregory H. Tyson, Olgica Ceric, Michael J. Stanhope, Laura B. Goodman. (2024) Data from: Evolutionary genomic analyses of canine E. coli infections identifies a relic capsular locus associated with resistance to multiple classes of antimicrobial drugs. [dataset] Cornell University eCommons Repository. https://doi.org/10.7298/pdzk-rq02
dc.description.abstractThese files contain data that support hypotheses presented in Ceres et. al. Evolutionary genomic analyses of canine E. coli infections identifies a relic capsular locus associated with resistance to multiple classes of antimicrobial drugs. In Ceres et. al. we found: Escherichia coli is the leading cause of death attributed to antimicrobial resistance (AMR) worldwide, and the known AMR mechanisms involve a range of functional proteins. Here we employed a pan-GWAS approach on over 1,000 E. coli isolates from sick dogs collected across the US and Canada and identified a strong statistical association of AMR, involving a range of antibiotics, to a group 1 capsular (CPS) gene cluster. This cluster included genes under relaxed selection pressure, had several loci missing, and pseudogenes for other key loci. It is widespread in E. coli and Klebsiella infections across multiple host species. Earlier studies demonstrated that the octameric CPS polysaccharide export protein Wza can transmit macrolide antibiotics into the E. coli periplasm. We suggest the CPS in question, and its highly divergent Wza, functions as an antibiotic trap, preventing drug penetration. We also highlight the high diversity of lineages circulating in dogs across all regions studied, overlap with human lineages, and regional prevalence of resistance to multiple drug classes.
dc.description.sponsorshipThis work was supported (FOA PAR-18-604) and performed in collaboration with the US Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network under grants 1U18FD006993 to Cornell; 1U18FD006442 to Louisiana State; 1U18FD006712 to Ohio ADDL; 1U18FD006862 and 1U18FD007244-to University of Guelph; 1U18FD006558 to South Dakota, 1U18FD006453- to Washington State.
dc.identifier.doihttps://doi.org/10.7298/pdzk-rq02
dc.identifier.urihttps://hdl.handle.net/1813/114262
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectantimicrobial drug resistance
dc.subjectrelaxed selection
dc.subjectantibiotic resistance
dc.titleData from: Evolutionary genomic analyses of canine E. coli infections identifies a relic capsular locus associated with resistance to multiple classes of antimicrobial drugs
dc.typedataset

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