This Falkenhain_etal_2020_readme.txt file was generated on 2020-05-02 by Oliver Bracko





GENERAL INFORMATION



1. Title of Dataset: Data from: A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease



2. Author Information

	A. Principal Investigator Contact Information

		Name: Oliver Bracko

		Institution: Cornell University

		Address: B54 Weil Hall, 14853, Ithaca, NY

		Email: ob84@cornell.edu



	B. Associate or Co-investigator Contact Information

		Name: Chris B. Schaffer

		Institution: Cornell University

		Address: B54 Weil Hall, 14853, Ithaca, NY

		Email: cs385@cornell.edu



	C. Alternate Contact Information

		Name: Kaja Falkenhain

		Institution: University of British Colombia

		Address: Canada

		Email: kajaf@mail.ubc.ca



3. Date of data collection: 2019/01/01--2019/07/31



4. Geographic location of data collection: Ithaca, NY, USA



5. Information about funding sources that supported the collection of the data: DFG German Research Foundation, National Science Foundation Graduate Research Fellowship, the German National Academic Scholarship Foundation, Affinito-Stewart Grant of the President’s Council of Cornell Women, the National Institutes of Health grants AG049952 and NS108472, and the BrightFocus Foundation.





SHARING/ACCESS INFORMATION



1. Licenses/restrictions placed on the data: These data are shared under a Creative Commons Attribution 4.0 International License, https://creativecommons.org/licenses/by/4.0/. The data are available for sharing and re-use, but attribution to the original authors is required.



2. Links to publications that cite or use the data:
Falkenhain K, Ruiz-Uribe NE, Haft-Javaherian M, Ali M, Stall Catchers, Michelucci PE, Schaffer CB, and Bracko O. (2020) A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease. PLOS ONE. https://doi.org/10.1371/journal.pone.0235691


3. Links to other publicly accessible locations of the data:



4. Links/relationships to ancillary data sets:



5. Was data derived from another source? NO

	A. If yes, list source(s):



6. Recommended citation for this dataset: Falkenhain, Kaja; Ruiz-Uribe, Nancy E.; Haft-Javaherian, Mohammad; Ali, Muhammad; Michelucci, Pietro E.; Schaffer, Chris B.; Bracko, Oliver (2020). Data from: A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease. [Dataset]. Cornell University Library eCommons Repository. https://doi.org/10.7298/3fmv-rf23






DATA & FILE OVERVIEW



1. File List:

Files are presented by figure from the related publication.
  There is also an "ExcelArchivalFiles" folder that contains some original excel files (that were converted to CSV for repository deposit), and csv files with lists of the original formulas from other excel files that were converted to CSV.


2. Relationship between files, if important:



3. Additional related data collected that was not included in the current data package:



4. Are there multiple versions of the dataset? NO

	A. If yes, name of file(s) that was updated:

		i. Why was the file updated?

		ii. When was the file updated?






METHODOLOGICAL INFORMATION



1. Description of methods used for collection/generation of data: All imaging data has been taken with a home build two-photon microscope.
Behavioural data has been taken with the viewer software (http://www.biobserve.com)
Exercise was performed on ENV-047; Med Associates, Inc.low-profile wireless running wheel and data was collected with Wheel Manager Software (SOF-860; Med Associates, Inc)


2. Methods for processing the data:

All imaging data was corrected for motion artefacts using Matlab
Blood flow analyses was performed on the images using Matlab
Capillary stalling data was prepared by Deepvess (in house code: an be received from cs385@cornell.edu) and analyses in the citizen science game (wwww.stallcatchers.com)


3. Instrument- or software-specific information needed to interpret the data:

<include full name and version of software, and any necessary packages or libraries needed to run scripts>

Prism 8 version 4.2
Matlab Version R2018a
Blood flow data has been analyses with in house written codes (can be received from cs385@cornell.edu)
Imaris version 9.2.1
Biobserve Viever teaching software
Image J, NIH